Clinical characteristics of patients with hospital-acquired infections caused by carbapenem-resistant gram-negative bacteria and effectiveness of AMS
10.11816/cn.ni.2025-246956
- VernacularTitle:2015-2023年某院耐碳青霉烯类革兰阴性菌医院感染临床特征及AMS防控成效
- Author:
Li XU
1
;
Danting JIN
;
Jie PANG
;
Yanan CHEN
Author Information
1. 连云港市第一人民医院护理部,江苏连云港 222000
- Publication Type:Journal Article
- Keywords:
Carbapenem-resistant gram-bacteria;
Epidemiology;
Antimicrobial stewardship;
Prevention and con-trol
- From:
Chinese Journal of Nosocomiology
2025;35(14):2164-2169
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To understand the clinical distribution of carbapenem-resistant gram-negative bacteria(CR-GNB)hospital-acquired infections and observe the effectiveness of antimicrobial stewardship(AMS)so as to pro-vide theoretical basis for targeted supervision.METHODS The patients who were detected with CR-GNB in the First People's Hospital of Lianyungang from Jan.1,2015 to Dec.31,2023 were monitored by hospital-ac-quired infection informatization monitoring system,the demographic and etiological data were collected from the patients with hospital-acquired infections,the clinical characteristics were analyzed.The incidence of CR-GNB in-fections,isolation rates and drug administration indexes were observed and compared,and the effectiveness of AMS was evaluated.RESULTS A total of 972 633 hospitalized patients were monitored,1319 of whom had hospi-tal-associated CR-GNB infections,and the total incidence of infections was 0.17％,showing a continuously down-ward trend during the years(P＜0.001).Carbapenem-resistant Acinetobacter baumannii(43.37％),carbapenem-resistant Pseudomonas aeruginosa(29.72％)and carbapenem-resistant Klebsiella pneumoniae(24.94％)ranked the top 3 species of pathogens.The CR-GNB infections were most prevalent in intensive care unit(ICU),followed by geriatrics department and neurosurgery department.Lower respiratory tract was the predominant infection site.The patients of male,no less than 65 years of age,and ICU stay were at higher risk of CR-GNB infections than other populations(P＜0.001).The implementation of AMS reduced the incidence of CR-GNB infections,iso-lation rates,utilization rates of antibiotics,antibiotics prophylaxis rates for type Ⅰ incision surgery and antibiotics use density(P＜0.05).CONCLUSIONS The hospital-associated CR-GNB infection show"U"type epidemiological characteristics.It is necessary to focus on the population characterized by male/the elderly/ICU stay.The imple-mentation of AMS may effectively facilitate the control and detection rate of the CR-GNB infections.
