Progress on recombinant viral vector vaccines of African swine fever

VernacularTitle:非洲猪瘟病毒载体疫苗的研究进展
Author: Yunyun MA ¹ ; Wei LIU ¹ ; Haiyan LU ¹ ; Shandian GAO ¹ ; Junjun SHAO ¹ ; Huiyun CHANG ¹
Author Information

1. 中国农业科学院兰州兽医研究所动物疫病防控全国重点实验室,甘肃兰州 730046
Publication Type:Journal Article
Keywords: African swine fever; African swine fever virus; viral vector; vaccine
From: Chinese Journal of Veterinary Science 2025;45(4):859-866
CountryChina
Language:Chinese
Abstract: African swine fever(ASF)caused by African swine fever virus(ASFV)is a febrile,hem-orrhage and highly fatal infectious disease in pigs,which poses a serious threat to the global pig in-dustry.Currently,no vaccine is available for the prevention and control of ASF,and several ASF vaccines,including gene deletion attenuated live vaccines,live vector vaccines,and subunit vaccines are under the development stage in the laboratory research.As one of the most promising vaccines,live vector vaccine has the characteristic of safety and simulation of the pathogen natural infection to effectively stimulate the innate and adaptive immune responses,which becomes one of the hotspots in the research and development of novel ASF vaccines.This review focuses on the pro-gress in using modified viruses as vectors for ASF live vector vaccines,and aims to provide valua-ble information for future development of safe and effective ASF vector vaccines.