Trends of drug resistance rate of Acinetobacter baumannii strains isolated from intensive care medicine department of a three-A hospital from 2017 to 2024
10.11816/cn.ni.2025-248675
- VernacularTitle:2017-2024年某三甲医院重症医学科鲍曼不动杆菌耐药率变迁
- Author:
Liwei ZHANG
1
;
Chengyi FENG
;
Pengfei WANG
;
Lili ZHU
;
Dan JIN
;
Shufang JIANG
;
Jia DI
Author Information
1. 常州市第一人民医院感染管理处,江苏 常州 213003
- Publication Type:Journal Article
- Keywords:
Critical care medicine department;
Acinetobacter baumannii;
Carbapenem-resistant Acinetobacter bau-mannii;
Distribution of specimens;
Change of drug resistance
- From:
Chinese Journal of Nosocomiology
2025;35(13):2001-2006
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To observe the isolation rates and drug resistance rates of Acinetobacter baumannii strains isolated from intensive care unit(ICU)patients in 8 consecutive years so as to provide bases for reasonable clinical application of antibiotics and control of infections.METHODS The isolation rates and specimens from which the A.baumannii and carbapenem-resistant A.baumannii(CRAB)strains were isolated from ICU patients of the First People's Hospital of Changzhou between 2017 and 2024 were retrospectively analyzed.The trends of the drug resistance rates were observed.RESULTS Totally 2078(18.03％)strains of A.baumannii were isolated from the ICU patients from 2017 to 2024,and there was no significant difference in the changing trend among the years(x2=-1.573,P=0.116).Among the A.baumannii strains that were isolated from 2017 to 2024,58.08％were isolated from sputum,and 24.25％from lavage fluid specimens;the percentage of sputum specimens showed a downward trend in the 8 years(x2=-8.257,P＜0.001),while the percentage of lavage fluid speci-mens showed an upward trend(x2=12.964,P＜0.001).The isolation rate of the CRAB strains was 91.48％in 2017,92.61％in 2018,92.56％in 2019,82.53％in 2020,52.44％in 2021,showing a down-ward trend,and it began to rise in 2022-2024,there was significant difference(x2=-2.277,P=0.012).The isolation rates of the CRAB strains from both sputum and lavage fluid specimens showed downward trends and then upward trends(all P＜0.05).The drug resistance rates of the A.baumannii strains to piperacillin and minocycline showed slow upward trends,while the drug resistance rates to gentamicin and tigecycline showed downward trends,and there were significant differences(P＜0.05).The drug resistance rates of the A.bau-mannii strains to imipenem and meropenem remained more than 90％.CONCLUSIONS Acinetobacter spp is the major pathogen causing the hospital-acquired infection.The isolation rate of CRAB strains shows a downward trend then a upward trend in recent two years.It is necessary for the hospital to standardize the submission of spu-tum specimens and increase the aseptic submission.The A.baumannii strains show high drug resistance rates to the commonly used antibiotics.Polymyxin B,tigecycline and minocycline are the major antibiotics for treatment of CRAB infection.
