Progress of research on biofilm formation and treatment of Escherichia coli
10.11816/cn.ni.2025-242010
- VernacularTitle:大肠埃希菌生物膜形成及其治疗研究进展
- Author:
Jingru ZHANG
1
;
Zhenwei HUANG
;
Ziling LIU
Author Information
1. 内蒙古科技大学包头医学院研究生院,内蒙古包头 014040;包头市中心医院检验科,内蒙古包头 014040
- Publication Type:Journal Article
- Keywords:
Escherichia coli;
Biofilm;
Treatment;
Formation mechanism;
Antibiotic;
Druy resistance mechanism
- From:
Chinese Journal of Nosocomiology
2025;35(14):2225-2229
- CountryChina
- Language:Chinese
-
Abstract:
The biofilm is a major pathogenic factor for many types of chronic infections,and Escherichia coli bio-film plays an important role in community-acquired infection and hospital-acquired infection and is one of common causes of urinary tract infection(UTI).The quorum sensing(QS)system of E.coli biofilm can mediate intercel-lular information exchange and thus regulate the whole community to adapt to the environmental changes,and the extracellular matrix-derived complex resistance mechanisms lead to a certain degree of bacterial resistance to anti-microbial drugs and resistance to immune system,which then makes it difficult for the conventional antimicrobial drugs to effectively eradicate the biofilm-associated infections.The article focuses on the formation of E.coli bio-film,drug resistance mechanisms and treatment aspects and summarizes the progress of research on the novel substitutive therapies against the E.coli biofilms that were developed in recent years,such as phytochemicals,nanomaterials,probiotics and phage therapy,so as to provide theoretical bases for the clinical treatment and the development of novel drug therapies against the E.coli biofilm.
