Progress of researchs on drug resistance mechanisms and clinical antimicrobial treatment of carbapenem-resistant Enterobacteriaceae infections
10.11816/cn.ni.2025-246839
- VernacularTitle:耐碳青霉烯类肠杆菌感染的耐药机制及临床抗菌治疗研究进展
- Author:
Lijuan LI
1
;
Ziyang YUAN
;
Haixing MO
;
Lu ZHANG
;
Lisha LAI
;
Wenjin FU
Author Information
1. 广东医科大学第一临床医学院,广东湛江 524023;南方医科大学第十附属医院东莞市人民医院检验科,广东东莞 523059;东莞市厚街医院检验科,广东东莞 523945
- Publication Type:Journal Article
- Keywords:
Carbapenem-resistant Enterobacteriaceae;
Epidemiology;
Drug resistance mechanism;
Carbapene-mase;
Antibiotic
- From:
Chinese Journal of Nosocomiology
2025;35(14):2219-2224
- CountryChina
- Language:Chinese
-
Abstract:
The drug resistance of the carbapenem-resistant Enterobacteriaceae(CRE)strains was mainly induced by multiple approaches such as production of carbapenemases,increase of bacterial outer membrane permeability,activation of active efflux pump system,formation of biofilm and drug modifying mechanisms.Those mecha-nisms involve deletion,mutation,insertion and posttranscriptional modification of relevant encoding genes,which may affect the susceptibility of the CRE strains to antibiotics.At present,the conventional clinical thera-pies include the use of traditional antibiotics,either the one-drug use or combined use of drugs.The development of novel antibacterial therapy is under way.The epidemiological characteristics of CRE infections,drug resist-ance mechanisms,current and prospective treatment strategies for CRE infections(covering new application of the drugs in available,the novel drugs such as ceftazidime/avibactam,meropenem/vaborbactam and imipenem/rele-bactam)were deeply reviewed in this article,so as to provide reliable reference for clinical prevention,control and treatment of CRE infections.
