Effect of neutrophil extracellular traps on fighting against influenza virus infection and progress of research on active inhibitors
10.11816/cn.ni.2025-241418
- VernacularTitle:中性粒细胞胞外诱捕网在机体抗流感病毒感染中的作用及其活性抑制剂研究进展
- Author:
Nonghan WANG
1
;
Xinyu SONG
;
Xiaolong WANG
Author Information
1. 山东中医药大学实验中心,山东济南 250355;山东中医药大学中医药创新研究院,山东济南 250355
- Publication Type:Journal Article
- Keywords:
Influenza virus;
Neutrophil extracellular traps;
Acute lung injury;
Active inhibitor;
Targeted treat-ment;
Inflammatory response
- From:
Chinese Journal of Nosocomiology
2025;35(13):2057-2062
- CountryChina
- Language:Chinese
-
Abstract:
As one type of immune cells commonly exiting in the lungs,neutrophils play a critical role in fighting a-gainst the influenza virus infection.On the other hand,neutrophils play a key role in the development of acute lung injury caused by viral infection.When the virus invades the human body,a large number of neutrophils gath-er in lungs and are activated to release various types of proteases,which may form the neutrophil extracellular traps(NETs)to defend the virus's invasion.However,NETs may also lead to uncontrolled inflammatory re-sponses,including direct cell damage,recruitment of other pro-inflammatory cells/inflammatory mediators,and formation of autoantibodies;the continuous formation of NETs under hyperinflammatory state is a driven factor to induce the immune damage of the human body.This review aims to summarize the effect of NETs on pathoge-netic process of influenza virus infection and illustrates the application of NETs active inhibitors in fighting against the virus infection so as to provide reference for developing targeted NETs drugs for treatment of influenza.
