Rationality and safety of clinical application of ceftazidime-avibactam
10.11816/cn.ni.2025-246768
- VernacularTitle:头孢他啶/阿维巴坦临床应用的合理性及安全性评价
- Author:
Danli TIAN
1
;
Ying XIAO
;
Xiaochen WEI
;
Weiwei LI
;
Haixia REN
Author Information
1. 天津市第一中心医院药学部,天津 300192
- Publication Type:Journal Article
- Keywords:
Ceftazidime-avibactam;
Clinical application;
Drug-induced adverse reaction;
Rationality;
Anti-infection
- From:
Chinese Journal of Nosocomiology
2025;35(13):2045-2049
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To comprehensively assess the rationality and safety of clinical application of ceftazidime-avibactam(CAZ/AVI)so as to provide bases for reasonable and safe application of the drugs.METHODS A total of 137 patients who were hospitalized in Tianjin First Central Hospital and were treated with CAZ/AVI from Jan.2023 to Jan.2024 were recruited as the research subjects.The relevant informations involving the baseline da-ta,infection sites,etiological tests,status of drug utilization and adverse reactions were investigated and statically analyzed.The rating form was designed based on relevant guideline consensus and package insert,and the rational-ity and safety of clinical application of days were evaluated.RESULTS Totally 137 valid cases were enrolled in the study,88(64.23％)of whom were male,and 49(35.77％)were female,with the mean age(52±21.89)years old and the average medication duration(12.2±6.45)days.Totally 79 case-times of drug administration were un-reasonable,involving 75 patients;unsuited indications,unreasonable treatment course,absence of special consul-tation and ward round records and no curative effect evaluation after drug administration for 48-72 hours were the major manifestations.The total effective rate of CAZ/AVI treatment was 87.62％,5 patients had CAZ/AVI-associated adverse reactions,with the incidence of adverse reactions 3.65％.CONCLUSION It is necessary for the hospital to further standardize and optimize the clinical utilization of CAZ/AVI,strictly conform to the medica-tion indications,and strengthen the medication surveillance so as to raise the rationality and safety of medication.
