Impact of gut microbiota dysbiosis on the healing of open limb fractures and corresponding intervention strategies: a review
10.3760/cma.j.cn501098-20250417-00228
- VernacularTitle:肠道菌群失调对四肢开放性骨折愈合的影响及其干预策略研究进展
- Author:
Jianhui ZHU
1
;
Yue MA
;
Xingwen HAN
Author Information
1. 兰州大学第一临床医学院，兰州 730000
- Publication Type:Journal Article
- Keywords:
Fractures, open;
Limb;
Fracture healing;
Gastrointestinal tract;
Gut microbiota
- From:
Chinese Journal of Trauma
2025;41(10):1008-1014
- CountryChina
- Language:Chinese
-
Abstract:
Open limb fractures, often caused by high-energy trauma, are frequently complicated by bacterial contamination, which can lead to delayed wound healing, impaired fracture union, or nonunion. The pathophysiological changes following the fractures can induce a series of alterations in the gut microbiota and their metabolites, resulting in gut microbial dysbiosis that adversely affects open limb fracture healing. Restoring the balance of the gut microbiota may help modulate immune responses and bone metabolism in patients, thereby promoting open fracture repair. Currently, there is no comprehensive summary of the relationship between gut microbiota and open limb fractures or the mechanisms by which gut microbiota interventions regulate fracture healing. Therefore, the authors reviewed the recent advances in the impact of gut microbiota dysbiosis on open limb fracture healing and corresponding intervention strategies, aiming to provide a reference for developing integrated fracture treatment approaches based on microbiome regulation.
