Multiple biomarker analysis for influence of gram-negative bacterial infection on prognosis of heart failure patients with reduced ejection fraction
10.11816/cn.ni.2025-241992
- VernacularTitle:基于多重生物标志物分析革兰阴性菌感染对射血分数降低型心力衰竭患者预后的影响
- Author:
Chuan YU
1
;
Wei XU
;
Xiaoyu ZHOU
;
Lijun LONG
;
Ji LI
Author Information
1. 贵州医科大学第二附属医院心血管内科一病区,贵州凯里 556000
- Publication Type:Journal Article
- Keywords:
Multiple biomarker analysis;
Gram-negative bacterium;
Heart failure with reduced ejection fraction;
Biomarker;
Rehospitalization rate
- From:
Chinese Journal of Nosocomiology
2025;35(12):1781-1786
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the influence of gram-negative bacterial infection on the prognosis of patients with heart failure with reduced ejection fraction(HFrEF),and to explore its effects on biomarker dynamics,car-diac function recovery,rehospitalization rates and all-cause fatality rate.METHODS Clinical data were retrospec-tively collected from 100 patients diagnosed with HFrEF and combined with gram-negative bacterial infection at the Second Affiliated Hospital of Guizhou Medical University and the Cardiovascular Medicine of the Army Medi-cal Center of Chinese PLA from Jan.2022 to Jan.2024.Clinical baseline data,including demographic information,medical history and biomarkers[interleukin-6(IL-6),C-reactive protein(CRP),procalcitonin(PCT),brain natriuretic peptide(BNP),N-terminal pro-brain natriuretic peptide(NT-proBNP)and troponin]were collected through follow-up visits for 12 months.Follow-up visits were conducted at discharge,3 months,6 months and 12 months,left ventricular ejection fraction(LVEF),NYHA classification(New York heart asso-ciation functional classification for heart),rehospitalization status and all-cause fatality rate were recorded.RESULTS Gram-negative bacterial infection significantly increased the rehospitalization and all-cause fatality rates in patients with HFrEF.The cumulative rehospitalization rate reached 45.00％within 12 months,and the all-cause fatality rate was 15.00％(P＜0.05).Inflammatory markers such as IL-6 and CRP were significantly ele-vated at baseline(P＜0.001)and decreased at discharge,while NT-proBNP levels were higher during the follow up period than those after the discharge,positively correlating with the numbers of rehospitalizations and fatality rates(r=0.752,P＜0.001).LVEF and NYHA classification improved in the short term but showed poor long-term prognosis.CONCLUSIONS Gram-negative bacterial infection significantly affects the long-term prognosis of patients with HFrEF,exacerbating cardiac function damage through inflammatory responses,thus increases re-hospitalization and fatality rates.This study provides new directions for clinical management,and emphasize the importance of early infection control.
