Research progress on the mechanism of antimicrobial peptide modulation of bacterial drug resistance
10.11816/cn.ni.2025-241212
- VernacularTitle:抗菌肽调控细菌耐药机制的研究进展
- Author:
Pin LU
1
;
Huiru ZHOU
1
;
Jing ZHAO
1
;
Xue ZHANG
1
;
Yajun JIAO
1
;
Liqin ZHANG
1
Author Information
1. 甘肃省人民医院重症医学科,甘肃兰州 730000
- Publication Type:Journal Article
- Keywords:
Antimicrobial peptide;
Bacterial resistance;
Regulatory mechanism;
Research progress;
Treatment of infection
- From:
Chinese Journal of Nosocomiology
2025;35(11):1749-1755
- CountryChina
- Language:Chinese
-
Abstract:
The problem of drug resistance resulting from the long-term use of antimicrobials is a serious threat to global health,and the emergence of multidrug-resistant bacteria,in particular,has greatly limited therapeutic op-tions.Therefore,the development of new or alternative antimicrobial agents has become an urgent need.Antimi-crobial peptides(AMPs)have been regarded as good alternatives to antibacterial drugs due to their strong antibac-terial activity and unique mechanism of action.At present,some AMPs have completed preclinical studies on drug-resistant bacterial infections and entered the clinical trial stage,while their stability and targeting have been signifi-cantly improved through the optimisation of amino acid modification,nano-delivery system and other technolo-gies,which have gradually become a research hotspot in this field.Therefore,this paper discusses the importance of AMPs in bacterial drug resistance from the biological properties of AMPs,the mechanism of regulating bacteri-al drug resistance and the application of AMPs in the treatment of drug-resistant bacterial infections,with a view to providing a reference for the development of drugs against drug-resistant bacteria and clinical application.
