Potential mechanisms and research progresses in non-antimicrobial drugs in anti-infective therapies
10.11816/cn.ni.2025-246365
- VernacularTitle:非抗菌药物抗感染治疗的潜在机制及应用研究进展
- Author:
Yingying SUN
1
;
Yaozhou WU
;
Ruirui WANG
;
Lianhua WEI
Author Information
1. 甘肃中医药大学公共卫生学院,甘肃兰州 730000
- Publication Type:Journal Article
- Keywords:
Drug repurposing;
Non-antimicrobial drug;
Bacterial resistance;
Antimicrobial mechanism;
Anti-infec-tion therapy
- From:
Chinese Journal of Nosocomiology
2025;35(11):1735-1742
- CountryChina
- Language:Chinese
-
Abstract:
Bacterial drug resistance has become one of the public health threats facing humanity.When bacteria de-velop resistance to multiple antimicrobial agents,infections become difficult to control,often requiring the use of drugs with greater toxicity or higher doses of antimicrobial agents,posing unprecedented challenges to clinical an-ti-infective treatment.Therefore,there is an urgent need to develop new antimicrobial drugs.However,the devel-opment of antimicrobial drugs is confronted with high costs,a lack of new targets,and insufficient market incen-tives,all of which have led to slow progress in new drug development.Anti-infective therapy using non-antimicro-bial drugs with known pharmacology and toxicology has become a research hotspot,opening up new avenues for antimicrobial therapy.This article reviews the latest research progress on the anti-infective effects of nonsteroidal anti-inflammatory drugs,antidepressants,statins,antihypertensive drugs,antidiabetic drugs,antitumor drugs,antiplatelet drugs,antihistamines,sex hormones,local anesthetics,proton pump inhibitors,and anthelmintics,and summarizes their antimicrobial mechanisms.This not only expands our understanding of the anti-infective properties of these drugs but also promotes their re-evaluation and reutilization in clinical practice,providing new strategies for addressing the issue of bacterial resistance.
