Relationship between FGFR2 gene polymorphisms rs3135718 and rs1219648 with breast cancer risk and protein expression in Chinese women
10.3969/j.issn.1009-9905.2025.05.003
- VernacularTitle:FGFR2基因rs3135718和rs1219648多态位点与中国女性乳腺癌发病风险及其蛋白表达的关系
- Author:
Fu-rong HUANG
1
;
Yang LIU
1
;
Hong REN
1
;
Yong-dong JIANG
1
Author Information
1. 哈尔滨医科大学附属肿瘤医院 乳腺外科一病区(黑龙江 哈尔滨 150001)
- Publication Type:Journal Article
- Keywords:
Fibroblast growth factor receptor-2;
Breast neoplasms;
Single nucleotide polymorphism;
Genetic sus-ceptibility
- From:
Chinese Journal of Current Advances in General Surgery
2025;28(5):350-354
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between fibroblast growth factor receptor-2(FGFR2)gene polymorphisms and the risk of breast cancer and its protein expression in Han women from Heilongjiang,China.Meth-ods:Using the Snapshot technique for multiplex single nucleotide polymorphism genotyping,the polymorphisms rs3135718 and rs1219648 of FGFR2 were analyzed in 747 breast cancer patients and 716 healthy controls.Logistic re-gression was used to examine the association between these genotypes and breast cancer susceptibility.In a subset of 338 cases,immunohistochemistry was performed to assess FGFR2 protein expression,and chi-square tests was used to analyze the relationship between polymorphisms and protein expression.Results:The genotype frequencies of FGFR2 rs3135718 and rs1219648 showed significant differences between the breast cancer and control group.Logistic regression revealed that,for rs3135718,the CT,CC,and CT+CC genotypes were associated with increased breast cancer risk compared to the TT genotype(OR=1.280,95%CI:1.003-1.633;OR=1.500,95%CI:1.112-2.023;OR=1.341,95%CI:1.066-1.688).For rs1219648,the GA,GG,and GA+GG genotypes were significantly associated with higher breast cancer risk compared to the AA genotype(OR=1.352,95%CI:1.063-1.719;OR=1.826,95%CI:1.361-2.504;OR=1.475,95%CI:1.175-1.852).However,no significant association was found between FGFR2 rs3135718 and rs1219648 polymorphisms and FGFR2 protein expression(χ2=0.052,P=0.820;χ2=0.117,P=0.732).Conclusion:FGFR2 gene poly-morphisms rs3135718 and rs1219648 are significantly associated with breast cancer susceptibility in Han women from Heilongjiang,China,but these polymorphisms do not show a clear relationship with FGFR2 protein expression.
