Analysis of the metabolic regulatory mechanism of GLP-1 receptor agonist in overweight or obese patients with type 2 diabetes mellitus based on intestinal flora
10.3969/j.issn.1006-6187.2024.12.003
- VernacularTitle:基于肠道菌群分析胰高血糖素样肽1受体激动剂对超重或肥胖2型糖尿病患者代谢调控机制的研究
- Author:
Yang HU
1
;
Fuman DU
;
Yihong ZHANG
Author Information
1. 157011 牡丹江医学院
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Intestinal flora;
Liraglutide
- From:
Chinese Journal of Diabetes
2024;32(12):891-897
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of GLP-1 receptor agonist (GLP-1RA) on the intestinal flora of overweight or obese patients with type 2 diabetes mellitus (T2DM). Methods 20 newly diagnosed overweight/obese T2DM patients hospitalized in our hospital from September 2022 to February 2023,were treated with GLP-1RA Liraglutide for 3 months. General data and clinical indicators were collected before and after treatment respectively. 16SrDNA high-throughput sequencing was used to detect intestinal flora in fecal samples. Results Compared with group A,body weight,BMI,TC,TG,LDL-C,SBP,FPG,HbA1c and insulin resistance index (HOMA-IR) were decreased in group B (P<0.05),islet beta cell function index (HOMA-β) and HDL-C were increased (P<0.05). There was no change in the ɑdiversity of intestinal flora (P>0.05). The β diversity showed a clustered distribution. After treatment,the abundance of Betaproteobacteria,Pasteurellales,Pasteurellaceae,Clostridiaceae,Romboutsia,Clostridium,Peptostreptococcaceae,Haemophilus,Solobacterium,Bacteroides-cellulosilyticus increased. The abundance of Burkholderiales,Enterococcaceae and Enterococcus decreased. At the genus level,the abundance of Clostridium,Haemophilus,Romboutsia and Megamonas increased (P<0.05). Conclusions GLP-1RA can not only improve glucose and lipid metabolism,β cell function and insulin sensitivity in overweight/obese T2DM patients,but can also increase the abundance of beneficial bacteria and reduce the abundance of pathogenic bacteria.
