Drug resistance of pathogens of urinary tract infection and its epidemiological characteristics in a hospital from 2013 to 2023
10.11816/cn.ni.2025-246653
- VernacularTitle:2013-2023某院尿路感染病原菌耐药性及其流行病学特征
- Author:
Zhenglin CHANG
1
;
Jinzhao MO
;
Haojie WU
;
Jiayi LIU
;
Peng XU
;
Baoqing SUN
Author Information
1. 广州医科大学附属第一医院临床检验中心广州呼吸健康研究院,国家呼吸系统疾病临床研究中心,国家呼吸医学中心,广东 广州 510120
- Publication Type:Journal Article
- Keywords:
Urinary tract infection;
Midstream urine culture;
Pathogen;
Bacterial culture;
Drug resistance
- From:
Chinese Journal of Nosocomiology
2025;35(11):1711-1717
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To analyze the bacterial spectrum characteristics and drug resistance of midstream urine culture-positive cases in patients with urinary tract infection(UTI),and to provide reference for rational use of antibiotics.METHODS A retrospective analysis was conducted on 6 029 patients with urinary tract infections who had positive midstream urine cultures at the First Affiliated Hospital of Guangzhou Medical University from 2013 to 2023,with a total of 8 495 infectious bacterial detected,and the characteristics of the pathogens,antimicrobial susceptibility tests and the epidemiological features were analyzed.RESULTS There were 2 086 males and 3 943 fe-males.A total of 8 495 pathogens were isolated,of which 1 492 stains of gram-positive bacteria accounted for 17.56％,5 850 strains of gram-negative bacteria accounted for 68.86％,1 150 strains of fungi accounted for 13.54％,with Escherichia coli(42.30％),Klebsiella pneumoniae(7.59％),and Enterococcus faecalis(6.19％)being predominated.The major gram-negative bacteria had low resistance rates to meropenem,imipen-em and ertapenem(＜20％),and high resistance rates to ampicillin and cefazolin(＞34％).The major gram-posi-tive bacteria had low resistance rates to teicoplanin and quinupristin/dalfopristin(＜12％),very low resistance to linezolid(＜1％),and high resistance rates to erythromycin(＞40％).The main fungi had low resistance rates to flucytosine and amphotericin B(＜3％),while Candida tropicalis had high resistance rates to itraconazole,flu-conazole,and voriconazole(37.93％-42.18％).CONCLUSION The three most frequently isolated pathogens in the midstream urine cultures of patients with UTI are Escherichia coli,Klebsiella pneumoniae,and Group D En-terococcus faecalis,which show low resistance to tigecycline and high resistance to ciprofloxacin,ampicillin and levofloxacin,and these findings provide important references for clinical treatment of urinary tract infections.
