Characteristics of peripheral blood leukocyte morphology and scatterplot in severe fever with thrombocytopenia syndrome
10.11816/cn.ni.2025-242025
- VernacularTitle:发热伴血小板减少综合征外周血白细胞形态及散点图的特征
- Author:
Chen CHENG
1
;
Wenwen SHANG
1
;
Xiang QIAN
1
;
Jiexin ZHANG
1
;
Lixia ZHANG
1
Author Information
1. 南京医科大学第一附属医院检验学部,江苏南京 210029;国家医学检验临床医学研究中心分中心,江苏南京 210029
- Publication Type:Journal Article
- Keywords:
Severe fever with thrombocytopenia syndrome;
Infectious mononucleosis;
Hemorrhagic fever with re-nal syndrome;
Leukocyte morphology;
Scatterplot;
Leukocyte cell population data
- From:
Chinese Journal of Nosocomiology
2025;35(12):1793-1797
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To analyze the characteristics of peripheral blood leukocyte morphology,scatterplot and leukocyte cell population data(CPD)in patients with severe fever and thrombocytopenia syndrome(SFTS),infec-tious mononucleosis(IM)and hemorrhagic fever with renal syndrome(HFRS),and to explore their differences.METHODS Blood routine examination data were collected,including microscopic cell images,scatter-plots and leukocyte CPD study parameters from 44 patients diagnosed with SFTS,17 with IM and 11 with HFRS at the First Affiliated Hospital with Nanjing Medical University from Mar.2023 to May 2024.These data were compared with those of healthy controls to explore specific differences in the characteristics of peripheral blood leu-kocyte.RESULTS All 3 viral infections exhibited a left shift in the nucleus under the microscope,yet the blood routine scatterplot and microscopic leukocyte characteristics differed.SFTS commonly presented with a plasmacy-toid reactive lymphocyte with scattered points appearing in the upper reactive lymphocyte area of the scatterplot.IM showed a predominant irregular fried-egg-like reactive lymphocyte under the microscope,with the scatterplot typically presenting a rocket-like shape,in patients with HFRS,there was a significant increase in im-mature granulocytes in peripheral blood and plasmacytoid reactive lymphocyte scatter points with blue immature granulocyte scatter points visible.The fluorescence distribution width(MO-WY)of monocytes in the SFTS group was lower than those in the IM,HFRS and healthy control groups(P＜0.05).Compared to SFTS,IM and healthy control groups,the lateral scattered light distribution width(NE-WX)and fluorescence distribution width(NE-WY)of neutrophils in the HFRS group were both increased(P＜0.05).CONCLUSIONS There are signifi-cant differences in the characteristics of peripheral blood leukocyte morphology,scatterplot and CPD study param-eters among three viral infection diseases SFTS,IM and HFRS.These differences can provide early clinical advice and assist in clinical differentiation.
