Recent advances in identification methods for targets of natural bioactive molecules
- VernacularTitle:天然活性分子作用靶点识别方法研究进展
- Author:
Xiao-wen ZHANG
1
;
Ke-wu ZENG
Author Information
- Publication Type:Journal Article
- Keywords: natural products; drug target identification; meth-odology; chemical biology; proteomics; artificial intelligence
- From: Chinese Pharmacological Bulletin 2025;41(6):1047-1056
- CountryChina
- Language:Chinese
- Abstract: Natural products are bioactive components with me-dicinal value extracted from plants,animals and other natural sources.Historically,over half of innovative drugs have been de-rived from natural products or their derivatives.Identifying the molecular targets of these components in the human body is cru-cial for understanding their therapeutic mechanisms and develo-ping new drugs.Despite rapid advancements in target identifica-tion technologies,the elucidation of natural product targets still faces unique challenges.In recent years,researchers have devel-oped efficient methods for target identification by integrating chemical biology,proteomics,structural biology,and artificial in-telligence technologies,combined with molecular probe strate-gies.This article reviews the principles and practical applica-tions of current mainstream target identification techniques,pro-viding practical guidance for natural product research and drug development.
