Research progress on the effect of adipose tissue from different sites on islet β cell apoptosis
10.3969/j.issn.1006-6187.2024.12.013
- VernacularTitle:不同部位脂肪组织对胰岛β细胞凋亡影响的研究进展
- Author:
Yan SUN
1
;
Wenjiao WANG
1
;
Bin WU
1
Author Information
1. 650032昆明医科大学第一附属医院内分泌科
- Publication Type:Journal Article
- Keywords:
Obesity;
Diabetes mellitus,type 2;
Visceral adipose tissue;
Subcutaneous adipose tissue;
Islet β cells apoptosis
- From:
Chinese Journal of Diabetes
2024;32(12):951-953
- CountryChina
- Language:Chinese
-
Abstract:
The main pathogenesis of type 2 diabetes mellitus (T2DM) is pancreatic β cell apoptosis. Obesity is closely related to T2DM. Adipose tissue is divided into visceral adipose tissue and subcutaneous adipose tissue according to their different aggregation sites. The adipokines secreted by the adipose tissuefrom the two sites affect pancreatic β cell apoptosis by regulating endoplasmic reticulum stress,oxidative stress,and activation of inflammatory pathways. IL-8 acts on glucose metabolism through chemokine receptor 2 (CXCR2),and IL-8/CXCR2 axis differentially mediates pancreatic β cell apoptosis. This article reviews the research progress on the effects of adipose tissue from different sites on pancreatic β cell apoptosis.
