Establishment of prediction model for long-term prognosis of acute pulmonary embolism in internal medicine inpatients with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2024.12.009
- VernacularTitle:2型糖尿病内科住院患者急性肺栓塞远期预后预测模型的建立
- Author:
Xiaoyi DUN
1
;
Qin XUE
;
Yimin MA
;
Qinfen WU
Author Information
1. 830011乌鲁木齐,新疆医科大学第五附属医院血液科
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Acute pulmonary embolism;
Long-term prognosis;
Risk factor;
Prediction model
- From:
Chinese Journal of Diabetes
2024;32(12):923-927
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the long-term prognostic factors of acute pulmonary embolism (APE) among internal medicine inpatients with type 2 diabetes mellitus (T2DM),and establish a prediction model of long-term prognosis. Methods This study included 156 internal medicine inpatients with T2DM and APE (T2DM+APE group) admitted to internal medicine of Xinjiang 474 Hospital and The Fifth Affiliated Hospital of Xinjiang Medical University from July 2019 to June 2022. At the same time,156 inpatients with APE from the department of hematology were selected as APE group. All patients were fo llowed up for 1 year to evaluate the prognosis. Patients in T2DM+APE group were divided into good prognosis subgroup (n=108) and poor prognosis subgroup (n=48). The risk factors for poor prognosis were analyzed and a prediction model was established. Results The incidence of adverse events in T2DM+APE group was higher than that in APE group (P<0.05). Logistic regression analysis found that N-terminal precursor of B-type natriuretic peptide (NT-proBNP),cardiac troponin T (c-TnT),heart-type fatty acid binding protein (H-FABP) and simplified Pulmonary Embolism Severity Index (sPESI) score were risk factors for poor long-term prognosis of T2DM complicated with APE. The area under the curve(AUC),sensitivity and specificity of this model for predicting poor prognosis of T2DM complicated with APE were 0.938,83.3％ and 96.3％,which were higher than those of prediction with single indicator. Conclusions Patients with T2DM and APE have worse long-term prognosis than those with simple APE.The establishment of a prediction model is helpful for clinical evaluation of long-term prognosis.
