Research progress on regulation of hemoglobin hypoxia adaptation by erythrocyte protein complexes
- VernacularTitle:红细胞蛋白复合物调节血红蛋白缺氧适应的研究进展
- Author:
Ying-fei ZHANG
1
;
An-peng ZHAO
;
Rong WANG
;
Wen-bin LI
Author Information
- Publication Type:Journal Article
- Keywords: red blood cells; protein complex; band 3 protein; hemoglobin; conformational regulation; plateau hypoxia
- From: Chinese Pharmacological Bulletin 2025;41(6):1020-1025
- CountryChina
- Language:Chinese
- Abstract: The red blood cell membrane is an important place for signaling,material transport,energy exchange and other life activities inside and outside the erythrocyte,and its function is mainly realized by the protein complexes on the membrane sur-face.Glycoproteins,integrins,signaling proteins,channel pro-teins and other proteins that constitute the erythrocyte membrane protein complexes interact with each other through direct physi-cal effects or regulatory factor-mediated mechanisms,playing a role in regulating oxygen transport,maintaining cellular morphol-ogy and stability,participating in the regulation of signaling,as well as supporting the cytoskeleton and other functions.Hemo-globin is the mediator of oxygen transport and delivery in blood erythrocytes,and regulating its conformational changes can in-crease the efficiency of oxygen supply to alleviate hypoxia in plateau hypoxia.This review describes the composition,func-tion,interaction mechanism,and adaptive regulation of hemoglo-bin to hypoxia in erythrocyte membrane protein complexes,with the aim of providing new reference for the prevention of hypoxia symptoms,the formulation of therapeutic regimens and the devel-opment of anti-hypoxia drugs.
