Research progress of JNK signaling pathway in osteosarcoma
- VernacularTitle:JNK信号通路在骨肉瘤中的研究进展
- Author:
Qing-qing QIN
1
;
Yi-kun WANG
;
Qing-lin YANG
;
Yong-ping WANG
Author Information
- Publication Type:Journal Article
- Keywords: JNK; osteosarcoma; signaling pathways; miRNA; lncRNA; mechanism
- From: Chinese Pharmacological Bulletin 2025;41(6):1001-1005
- CountryChina
- Language:Chinese
- Abstract: Osteosarcoma(OS) is the most common primary bone malignancy with a high propensity for local infiltration and metastasis.c-Jun N-terminal kinases(JNK)is an extremely im-portant member of the mitogen-activated protein kinase(MAPK)family,and the JNK signaling pathway has been shown to be in-volved in regulating OS development.In this paper,we review the research progress on the JNK signaling pathway regulating biological behaviors such as proliferation,migration,invasion,an-giogenesis,autophagy,apoptosis and pyroptosis of OS,as well as the oxidative stress and non-coding RNA regulation of OS through the JNK signaling pathway,to further explore the intrin-sic regulatory mechanisms of the JNK signaling pathway,so as to provide a new way of thinking in searching for the treatment of OS.
