Effect of fasting blood glucose on coronary fractional flow reserve in patients with borderline coronary artery disease
10.3969/j.issn.1004-8812.2025.05.005
- VernacularTitle:冠状动脉临界病变患者空腹血糖与冠状动脉血流储备分数的相关性研究
- Author:
Yi-wen ZHANG
1
;
Ya-dong LIU
1
;
Meng-xiao WANG
1
;
Yi-ru WANG
1
;
Yun-peng YANG
1
;
Yun-fang SU
1
;
Ji-xin ZHI
1
Author Information
1. 哈尔滨医科大学附属第四医院心血管内科,黑龙江哈尔滨 150001
- Publication Type:Journal Article
- Keywords:
Fasting blood-glucose;
Fractional flow reserve;
Coronary microcirculation
- From:
Chinese Journal of Interventional Cardiology
2025;33(5):272-277
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between fasting blood glucose(FBG)level and fractional flow reserve(FFR)in patients with borderline coronary artery disease,and to clarify its potential influence on FFR measurement.Methods From August 2020 to August 2023,the data of 135 patients with coronary atherosclerotic heart disease who received coronary angiography and FFR evaluation in the Fourth Affiliated Hospital of Harbin Medical University were retrospectively collected.According to the exclusion and inclusion criteria,85 cases of borderline diseased vessels of single coronary artery with stenosis degree of 50％-80％were screened out,and they were divided into FBG≥6.1 mmol/L group(47 cases)and FBG＜6.1 mmol/L group(38 cases).The baseline data,angiographic and functional indexes of the two groups were compared,and the correlation between FBG and FFR was analyzed.Results Compared with the FBG＜6.1 mmol/L group,the FBG≥6.1 mmol/L group had a higher proportion of FFR negative results(72.3％vs.23.7％,P＜0.001),and the FFR measurement values were generally increased[0.84(0.80,0.90)vs.0.75(0.68,0.80),P＜0.001],with statistically significant differences.Pearson correlation analysis was performed on all lesions,and FFR＞0.80(negative result)was positively correlated with FBG≥6.1 mmol/L(r=0.484,P＜0.001).Conclusions Among the patients with borderline coronary artery disease(50％-80％stenosis)included in this study,FBG≥6.1 mmol/L is significantly correlated with FFR＞0.80.For patients with borderline coronary lesions with elevated FBG,the influence of blood glucose factors should be carefully considered in clinical interpretation of FFR results.
