Changes in intercellular adhesion molecules and effect on prognosis following hyperbaric intervention in patients with acute cerebral infarction
10.3760/cma.j.issn.1009-6906.2011.05.012
- VernacularTitle:高压氧干预下急性脑梗死患者细胞黏附分子变化及对预后的影响
- Author:
Yan LI
1
;
Feng HUANG
;
Tao HAN
;
Peng-wei CAI
;
Fa-lin CHEN
;
Bao-ying ZHOU
;
Kan LIN
;
Tian-qiang ZHANG
Author Information
1. 福建省立医院心血管病研究所高压氧室,福州,350001
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Intercellular adhesion molecule;
Acute cerebral infarction;
Neural function
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2011;18(5):296-300
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe dynamically the CD11b,CD11c and CD54 in patients with acute cerebral infarction (ACI),to find out the change pattern and the effect of HBO on the change pattern,to illustrate the protective effects of HBO on cerebrovascular lesion in patients with ACI,and to explore the correlation between the CD1 1b,CD1 1c and CD54 before therapy and near and long-term effects on neurological recovery.Methods Sixty-four cases of ACI were divided into the HBO + routine therapy group (31 cases) and the therapy control group with only routine therapy (33 cases).CD11b,CD11c and CD54 in the subjects of both groups were measured in 72 hours,and on the 7th,10th,12th and 20th days respectively following acute infarction,and neural functional damage scores (NDS) were also evaluated at the same time.CD1 1b,CD11c and CD54 of the subjects in the normal control group (25 cases) were also measured by taking blood samples from peripheral veins.Results The expression of CD11b,CD11c and CD54 in the HBO group and the control group increased obviously within 72 hours of onset,and reached peak value within 72 hours.No significant differences could be seen between the two groups (P ＞ 0.05).Then,the above data declined on the 7th day.CD11b,CD11c in the HBO group maintained at peak level for7 days,while those in the control group maintained for 10 days.CD54 peak value kept for 10 days in the HBO group,while peak value maintained for 12 days in the therapy control group.Correlation analysis and linear regression analysis indicated that NDS on the 20th day (short-term curative effect) and NDS within half a year and a year (long-term effect) were 97.2％,96.7％,97.6％ respectively,which could be explained with the up-regulation of CD11b and/or CD1 1c and/or CD54 and other related factors.Conclusions The duration of peak levels of CD11 b,CD1 1 c and CD54 in ACI patients could be shortened,following hyperbaric oxygen therapy.HBO might intervene in the changing process of intercellular adhesion molecule,shorten the duration of abnormal time,reduce their expression,protect ACI patients and reduce the adhesion of leukocytes.The expression of CD11b,CD11c and CD54 could predict the severity and prognosis of the disease,interfere with the short or long- term curative effects on the patients before therapy and reduce the damage of blood vessels.In addition,they could provide scientific basis for the regulation and control of CD11b,CD11c and CD54 expression,and the early development of a comprehensive treatment profile of the disease.
