Hypoperfusion intensity ratio of CT perfusion for predicting infarct core progression and prognosis of acute ischemic stroke
10.13929/j.issn.1003-3289.2025.05.005
- VernacularTitle:CT灌注成像低灌注强度比预测急性缺血性卒中梗死核心进展及预后
- Author:
Yao LU
1
;
Wenbo CAO
;
Jingkai LI
;
Miao ZHANG
;
Xiaolu FEI
;
Jie LU
Author Information
1. 首都医科大学宣武医院放射与核医学科,北京 100053;磁共振成像脑信息学北京重点实验室,北京 100053
- Publication Type:Journal Article
- Keywords:
ischemic stroke;
collateral circulation;
tomography,X-ray computed;
perfusion imaging
- From:
Chinese Journal of Medical Imaging Technology
2025;41(5):718-722
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of hypoperfusion intensity ratio(HIR)of CT perfusion(CTP)for predicting infarct core progression and prognosis of acute ischemic stroke(AIS).Methods Totally 271 AIS patients were retrospectively enrolled and divided into rapid progression group(group A,n=92)and slow progression group(group B,n=179)according to infarction growth rate(IGR).Clinical data,CTP parameters,treatment strategies and patients' outcome were compared between groups.Receiver operating characteristic curve was drawn,the area under the curve(AUC)was calculated to evaluate the efficacy of HIR for predicting rapid progression in infarct core of AIS.The mediating relationships among HIR,IGR and modified Rankin scale(mRS)90 days after treatment were analyzed.Results Significant differences of National Institute of Health stroke scale(NIHSS)score,Alberta stroke program early CT score(ASPECTS),also of interval time between onset and CTP,infarct core volume,hypoperfusion volume,HIR,whether intravenous thrombolysis and mRS score 90 days after treatments were found between groups(all P＜0.05).The AUC of HIR for predicting infarct core progression of AIS was 0.856,with sensitivity and specificity was 73.91％and 81.56％,respectively,when the optimal cutoff value was 0.42.IGR was a complete mediating variable between HIR and mRS score 90 days after treatment.Conclusion HIR of CTP could be used to effectively predict infarct core progression of AIS,which completely affected prognosis through mediating variable IGR.
