Tumor budding and its correlation with clinicopathological features and prognosis in penile squamous cell carcinoma
10.13315/j.cnki.cjcep.2025.05.009
- VernacularTitle:阴茎鳞状细胞癌肿瘤出芽与临床病理特征及预后的相关性
- Author:
Wen HAN
1
;
Qian ZHANG
;
Xiang YONG
;
Yi ZHANG
;
Chun WANG
;
Haonan LIU
;
Xiaotong GUO
Author Information
1. 新疆维吾尔自治区人民医院病理科,乌鲁木齐 830000
- Publication Type:Journal Article
- Keywords:
penile neoplasms;
squamous cell carcinoma;
tumor budding;
pathological features
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(5):608-613
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the correlation between tumor budding in penile squamous cell carcinoma(SCC)and its clinicopathological features.Methods Clinical data and pathological slides from 69 cases of penile SCC were collected.Tumor budding was examined microscopically,and statistical analyses were performed to assess the relationship between tumor budding and various clinicopathological features.Results Among the 69 cases of pe-nile SCC,41 cases exhibited low-grade tumor budding and 28 cases displayed high-grade tumor budding.Tumor bud-ding was significantly correlated with tumor size,urethral invasion,invasion of the urethral corpus spongiosum,inva-sion of the penile corpus cavernosum,tumor necrosis,nerve invasion,vascular tumor thrombus,and pathological T stage(all P＜0.05).In contrast,no significant association was found between tumor budding and HPV-related versus non-HPV-related penile SCC(P＞0.05).Log-rank survival analysis indicated that patients with high-grade tumor bud-ding had a significantly lower survival rate compared to those with low-grade tumor budding(P＜0.05).Conclusion Tumor budding is a distinct pathological feature of penile SCC,and high-grade tumor budding is associated with a more aggressive biological behavior.
