The molecular subtyping of urothelial carcinoma using GATA-3 and CD44
10.13315/j.cnki.cjcep.2025.05.007
- VernacularTitle:利用GATA-3、CD44等对尿路上皮癌进行分子分型的研究
- Author:
Xiaodie ZHOU
1
;
Bo YU
;
Xuan WANG
;
Jianjun WANG
;
Qunli SHI
;
Qiu RAO
;
Wei BAO
Author Information
1. 解放军东部战区总医院/南京大学医学院附属金陵医院病理科,南京 210002
- Publication Type:Journal Article
- Keywords:
urothelial carcinoma;
clinicopathology;
molecular typing;
CD44;
GATA-3
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(5):596-601
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the correlation between molecular typing of urothelial carcinoma(UC)and its clinicopathologic features and prognosis,in order to explore the prognostic markers and therapeutic targets for UC.Methods 115 patients with UC were retrospectively analyzed.Immunohistochemical markers GATA-3,CK20,CK5/6 and CD44 were used for molecular typing of UC(luminal-like type,basal-like type and null).Correlations between molecular typing and clinicopathological features were analyzed using the Chi-square test and Fisher precise test.Sur-vival analysis was performed using the Kaplan-Meier test and Log-rank test.Results The expression of GATA-3 and CK20 was negatively correlated with the clinical stage of UC,while the expression of CD44 was positively correlated with the clinical stage of UC(both P＜0.05).CK20 was a marker of good prognosis(P=0.03).The proportion of clinically advanced UC with basal-like type was significantly higher than that of luminal-like type(78.4％vs 53.4％,P=0.033).Among the histologic variants,UC with neuroendocrine differentiation(100％),sarcomatoid carcinoma(80.0％)and squamous differentiation(77.8％)were basal-like type.All plasmacytoid and lymphoepithelioma-like types,as well as 81.8％of micropapillary UC.Among the null phenotypes,the differential variant predominated(66.7％).Compared with the luminal-like type,although the prognosis of basal-like UC was worse,there was no sta-tistically significant difference(P＞0.05).Conclusion Patients with CK20-expressing UC had a significantly better prognosis.The main histologic variants types of basal-like type and coelomofacial type are different.Molecular typing of UC using immunohistochemical markers is suggestive of clinical staging and prognosis of patients.
