Analysis of medication rules for the treatment of cholelithiasis in patent compound based on data mining
10.3969/j.issn.1673-9701.2025.16.014
- VernacularTitle:基于数据挖掘专利复方治疗胆石症的用药规律
- Author:
Jiao WANG
1
;
Tingli SUN
;
Linlong XU
Author Information
1. 九江市第一人民医院呼吸内科,江西九江 332000
- Publication Type:Journal Article
- Keywords:
Cholelithiasis;
Medication rules;
Data mining;
Patent compound
- From:
China Modern Doctor
2025;63(16):57-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective Based on data mining,analyze the medication rules and formula characteristics for treating cholelithiasis in the national patent database.Methods Search the national patent database of China National Intellectual Property Administration for Chinese medicine compound formulas for treating cholelithiasis since the establishment of the database until January 2024,and used the Traditional Chinese Medicine(TCM)Inheritance Support System(V 2.5)to establish a database of Chinese medicine compound formulas and analyzed them through the platform and SPSS Modeler 18.0 to obtain the frequency of use of the medicines,nature and flavor,channel tropism,the rules of association,the complex network relationship,and the analysis of the complex entropy hierarchical clustering algorithm.Results A total of 305 Chinese medicine compound patents were included,and 478 Chinese medicines were recorded,among which the high frequency(＞50 times)Chinese medicines were Jinqiancao,Yujin,Yinchen,Chaihu,Jineijin,Dahuang,etc..The four qi of Chinese medicines were mainly based on the cold,the five flavors were based on the bitter,sweet,and pungent flavors,and the channel tropism were based on liver meridian,stomach meridian,spleen meridian,and gallbladder meridian.The most commonly used combinations of Chinese medicines were Jinqiancao paired with Yujin,Yinchen,Chaihu,Jineijin,and Dahuang,respectively.The entropy hierarchical clustering algorithm analyzed 4 groups of candidate new group formulas.Conclusion Traditional Chinese medicine for the treatment of cholelithiasis mainly focuses on the effects of clearing heat and promoting diuresis,promoting bile secretion and relieving jaundice,soothe the liver and regulate qi,and treatment should be based on the syndrome differentiation of the disease.The new prescription discovered in this study can provide a more accurate medication plan for the clinical use of cholelithiasis.
