Correlation between overactive bladder and neuropsychological characteristics in patients with cerebral small-vessel disease
10.3969/j.issn.1673-9701.2025.16.013
- VernacularTitle:脑小血管病患者膀胱过度活动症与神经心理特征的相关性研究
- Author:
Yuwei WANG
1
;
Wenhua DING
;
Jingjing QIU
;
LARE·Tuluhong KE
;
Yurong GENG
Author Information
1. 石河子大学第一附属医院神经内科,新疆石河子 832000
- Publication Type:Journal Article
- Keywords:
Cerebral small-vessel disease;
Dysuria;
Overactive bladder;
Neuropsychology
- From:
China Modern Doctor
2025;63(16):52-56
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between overactive bladder(OAB)and neuropsychological characteristics in patients with cerebral small-vessel disease(CSVD).Methods A total of 208 patients with CSVD admitted to the First Affiliated Hospital of Shihezi University from December 2023 to November 2024 were selected as research subjects.They were divided into OAB group(44 cases)and non-OAB group(164 cases)according to overactive bladder symptom score.The general information and imaging data of two groups of patients were compared.The cognitive function,anxiety and depression of patients were evaluated by using Montreal cognitive assessment(MoCA),digit span test(DST),auditory verbal learning test(AVLT),verbal fluency test(VFT),clock drawing test(CDT),Hamilton anxiety scale(HAMA)and Hamilton depression scale(HAMD).Logistic regression analysis was used to analyze the influencing factors of OAB in patients with CSVD.Pearson correlation analysis was used to analyze the correlation between imaging indicators and anxiety symptoms of patients in OAB group.Results The HAMA and HAMD scores of patients in OAB group were higher than those in non-OAB group(P＜0.05),but there were no statistically significant differences in MoCA,DST,AVLT,VFT,and CDT scores between two groups(P＞0.05).There was a statistically significant difference in the incidence of anxiety among patients with different degrees of OAB(P＜0.05).Multivariate Logistic regression analysis after adjusting for confounding factors showed that anxiety was an independent influencing factor for OAB in patients with CSVD(P＜0.05).The periventricular white matter hyperintensity of patients in OAB group was negatively correlated with the HAMA score(P＜0.05),while basal ganglia lacunar infarction,centrum semiovale lacunar infarction,basal ganglia enlarged perivascular space and centrum semiovale enlarged perivascular space were all positively correlated with the HAMA score(P＜0.05).Conclusion The anxiety and depression symptoms of patients with CSVD accompanied by OAB were more severe than those of non-OAB patients.Anxiety may be an independent influencing factor for the occurrence of OAB in patients with CSVD.
