Efficacy of urapidil combined with nimodipine in treatment of elderly hypertensive intracerebral hemorrhage
10.3969/j.issn.1009-0126.2025.06.015
- VernacularTitle:乌拉地尔联合尼莫地平治疗老年高血压脑出血的疗效研究
- Author:
Ping YAN
1
;
Jinyu MA
;
Chengwang HU
;
Xin NIU
;
Peng LIU
Author Information
1. 473000 河南省南阳医学高等专科学校第一附属医院神经内科
- Publication Type:Journal Article
- Keywords:
nimodipine;
hypertension;
cerebral hemorrhage;
hemodynamics
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(6):762-765
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of urapidil combined with nimodipine in the treatment of elderly hypertensive intracerebral hemorrhage(HICH).Methods A total of 128 elderly HICH patients admitted in our hospital from March 2022 to March 2024 were recruited and randomly di-vided into single group(64 cases)and combined group(64 cases).Both groups received routine treatment,and the single group was treated with urapidil while the combined group was given urapidil combined with nimodipine.Clinical efficacy,clinical indicators[cerebral hematoma vol-ume,intracranial pressure(ICP)],neurological function indicators[brain-derived neurotrophic factor(BDNF),neuron-specific enolase(NSE),nerve growth factor(NGF)],hemodynamic pa-rameters[perfusion index(PI),cerebrovascular reserve capacity(CVR),mean bilateral arterial flow velocity],and vascular endothelial function indicators[vascular endothelial growth factor(VEGF),endothelin-1(ET-1),angiopoietin-1(Ang-1)]were compared between the two groups.The incidence of adverse reactions was observed during treatment.Results The total effective rate was significantly higher in the combined group than the single group(89.06％vs 75.00％,P＜0.05).After treatment,the ICP,hematoma volume,PI,and levels of NSE,VEGF,ET-1 and Ang-1 in both groups were significantly lower than those before treatment(P＜0.05).These indi-cators in the combined group were significantly lower than those in the single group(P＜0.05,P＜0.01).The CVR,mean bilateral arterial flow velocity,and BDNF and NGF levels were notably increased in both groups after treatment,and the indicators were significantly higher in the com-bined group than the other group(P＜0.05,P＜0.01).There was no statistical difference in the incidence of adverse reactions between groups(P＞0.05).Conclusion Urapidil combined with ni-modipine can shrink the volume of cerebral hematoma,reduce ICP,and improve neurological function,hemodynamics and vascular endothelial function in elderly HICH patients,and the treat-ment does not increase the incidence of adverse reactions.
