Progress of research on quorum sensing and bacterial biofilm formation
10.11816/cn.ni.2025-250187
- VernacularTitle:群体感应系统与细菌生物膜形成的研究进展
- Author:
Jinhua ZHANG
1
;
Shujing GE
;
Jingyi REN
Author Information
1. 联勤保障部队第九七○医院卫勤处,山东烟台 264008
- Publication Type:Journal Article
- Keywords:
Bacterial biofilm;
Quorum sensing;
Acyl-homoserine lactone;
Autoinducer-2;
Indole
- From:
Chinese Journal of Nosocomiology
2025;35(10):1589-1594
- CountryChina
- Language:Chinese
-
Abstract:
The formation of bacterial biofilm imposes a formidable challenge to public health.Quorum sensing(QS),as a bacterial communication system with the capacity to sense bacterial density and modulate gene expres-sion,can regulate the formation of bacterial biofilm by regulating the secretion of bacterial basic substances and extracellular proteins and affecting the bacterial motility.At present,some QS inhibitors(QSI)from natural sources and synthesized QSI have become potential choice for treatment of bacterial infections for their inhibiting the formation of bacterial biofilm through inhibition of QS signaling pathways.The article focuses on the progress of research on the effects of QS and QSI on the formation of bacterial biofilm.
