Application of case-control study design in clinical research on hospital-acquired infections and specifications for report of results
10.11816/cn.ni.2025-246790
- VernacularTitle:病例对照研究设计在医院感染相关临床研究中的应用及其结果报告规范
- Author:
Huaihao LI
1
;
Shengshu WANG
;
Miao LIU
;
Yao HE
;
Shanshan YANG
Author Information
1. 解放军医学院,北京 100853;中国人民解放军总医院第二医学中心老年医学研究所,衰老及相关疾病研究北京市重点实验室,国家老年疾病临床医学研究中心,北京 100853
- Publication Type:Journal Article
- Keywords:
Hospital-acquired infection;
Case-control study;
Reporting specification;
Bias
- From:
Chinese Journal of Nosocomiology
2025;35(10):1572-1576
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To summarize the key points for design of case-control study,analyze the data and summa-rize the specifications so as to raise the quality of related clinical research on hospital-acquired infections.METHODS The types for design of the case-control study were systematically summarized based on the character-istics of hospital-acquired infection data with strong timeliness and various confounding factors.The design,data clearance and statistical analysis method were studied by analysis of typical cases,the common types for design of the case-control study and the key points of design were listed,and the specifications for report of the result of case-control study based on the clinical problems about hospital-acquired infections were summed up.RESULTS By starting from the key points for the design of the case-control study,the design framework of the study that con-tained three core elements was established based on the characteristics of related research on hospital-acquired in-fections,the three core elements were as follows:clarifying the temporal logic of exposure,developing strategies for the control of confounding factors,selecting appropriate statistical models.Meanwhile,the reporting specifica-tions were formulated to achieve the methodological transparency.CONCLUSION Clarifying the key points for de-sign of the case-control study and the specifications for report of results can improve the quality of clinical research on case-control design for hospital-acquired infection cases and boost the scientificity and feasibility.
