Delayed excretion of vancomycin due to over-frequency administration in a patient undergoing peritoneal dialysis
10.3760/cma.j.issn.1008-5734.2019.03.020
- VernacularTitle:超频次用药致腹膜透析患者万古霉素排泄延迟
- Author:
Jing YE
1
;
Yongfu HANG
;
Cheng XIE
Author Information
1. 苏州大学附属第一医院药学部 215006;新疆医科大学第五附属医院药学部,乌鲁木齐830011
- Publication Type:Journal Article
- Keywords:
Renal insufficiency,chronic;
Peritoneal dialysis;
Vancomycin;
Over-frequency administration;
Delayed excretion
- From:
Adverse Drug Reactions Journal
2019;21(3):239-240
- CountryChina
- Language:Chinese
-
Abstract:
A 44-year-old female patient with chronic kidney disease (stage 5) undergoing peritoneal dialysis received an Ⅳ infusion of vancomycin 500 mg once per 12 hours for infective endocarditis.Vancomycin was discontinued before the third administration for its frequency of administration was found inappropriate.The blood concentration of vancomycin was higher than 50 mg/L at 12 hours after the second dose.The blood concentration of vancomycin dropped to 9.2 mg/L after drug withdrawal and persistent peritoneal dialysis for 24 days.No other obvious adverse reactions related to vancomycin during this period.
