Survey of outbreak and whole genome tracing source of one case of suspected carbapenem-resistant Acinetobacter baumannii infection in ICU
10.11816/cn.ni.2025-246630
- VernacularTitle:ICU一起疑似耐碳青霉烯类鲍曼不动杆菌医院感染暴发调查及全基因组学溯源
- Author:
Keke LIU
1
;
Kexin WU
;
Heng CAO
;
Gui ZHANG
;
Yuqing LIU
;
Weiguang LI
Author Information
1. 山东省农业科学院畜牧兽医研究所中英噬菌体工程联合实验室,山东济南 250000;山东第一医科大学附属省立医院医院感染管理办公室,山东济南 250000
- Publication Type:Journal Article
- Keywords:
Carbapenem-resistant Acinetobacter baumannii;
Outbreak of hospital-associated infection;
Second gen-eration genome sequencing
- From:
Chinese Journal of Nosocomiology
2025;35(9):1412-1416
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To conduct the epidemiological survey for 4 patients with carbapenem-resistant Klebsiella pneumoniae(CRAB)that gathered to emerge in intensive care unit(ICU)within a short period so as to find out the sources of suspected CRAB.METHODS The clinical data and epidemiological history of the 4 patients with hospital-associated infection with CRAB who were treated in Shandong Provincial Hospital Affiliated to Shandong First Medical University from Mar.31,2023 to Apr.7,2023 were retrospectively analyzed.The whole genome second-generation sequencing was carried out for the CRAB strains isolated from the patients and their surround-ings,and the sources of the CRAB strains were traced by means of the whole genome sequencing.RESULTS The result of the epidemiological survey showed that the case 1,2,3 and 4 were close in spatial position and had the similar drug resistance spectrum,and there might be cross infection.With the combination of the result of genome analysis,it was found that the strain from the case 1 was brought from the community and was the evolutionary branch different from other CRAB strains causing nosocomial infection;the strains from the case 2,3 and 4 had the close original sources with the CRAB strains from surroundings.CONCLUSIONS The CRAB strain from the case 1 is brought from community,which differs in the evolution branch with the strains from the cases of hospi-tal-associated CRAB infection.The transmission of CRAB leading to the incident of suspected hospital-associated infection outbreak is multiple sources.It is an effective measure to early identify the outbreak of hospital-associated infection and take targeted prevention measures so as to control the outbreak of hospital-associated infection.
