Clinical effect of Bifidobacterium quadruple viable organisms combined with interferons on treatment of children with rotavirus-induced viral diarrhea
10.11816/cn.ni.2025-241228
- VernacularTitle:双歧杆菌四联活菌联合干扰素治疗轮状病毒感染性腹泻患儿的临床效果
- Author:
Dong SHAO
1
;
Jie CHEN
;
Jinling ZHAO
;
Jijuan DOU
;
Hongxue ZHENG
;
Guangyao ZHAO
Author Information
1. 江南大学附属医院儿科,江苏 无锡 214122
- Publication Type:Journal Article
- Keywords:
Infectious diarrhea;
Rotavirus;
Interferon;
Bifidobacterium quadruple viable organism;
Serum amyloid A;
Transforming growth factor-β;
25-hydroxyvitamin D3;
Intestinal function
- From:
Chinese Journal of Nosocomiology
2025;35(9):1367-1371
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To observe the impact of Bifidobacterium quadruple viable organisms combined with inter-ferons on serum amyloid A(SAA),transforming growth factor-β(TGF-β),25-hydroxyvitamin D3[25(OH)D3]and intestinal function of the children with rotavirus-induced viral diarrhea.METHODS A total of 88 children with rotavirus-induced viral diarrhea who were treated in Affiliated Hospital of Jiangnan University from Mar.2020 to Dec.2023 were recruited as the research subjects and were randomly divided into the conventional group with 44 cases(conventional symptomatic therapy plus interferons)and the combination group with 44 cases(the conven-tional symptomatic therapy plus Bifidobacterium quadruple viable organisms),and both groups were continuously treated for 5 days.The clinical curative effect and improvement of clinical symptoms were observed and compared between the two groups.The changes of peripheral blood immune function indexes,inflammatory factors,intesti-nal function indexes,SAA,TGF-β and 25(OH)D3 were analyzed.RESULTS There was no significant difference in the effective rate of treatment between the combination group and the conventional group after the treatment for 5 days(Z=1.375,P=0.169).The duration of stool property back to normal,fever abatement,number of defeca-tion times back to normal,cessation of diarrhea,virus turning to be negative and disappearance of abdominal pain was shorter in the combination group than in the conventional group(P＜0.05).The immune function,inflamma-tory factors and intestinal function indexes were improved more remarkably in the combination group than in the conventional group after the treatment for 5 days(P＜0.05).The levels of SAA,TGF-β and 25(OH)D3 of the combination group were respectively(3.84±0.35)pg/ml,(4.87±0.28)pg/ml and(50.63±7.14)pg/ml after the treatment for 5 days,higher than those of the conventional group.CONCLUSION Bifidobacterium quadruple viable organisms combined with interferons can effectively shorten the recovery time of clinical symptoms of the children with rotavirus-induced viral diarrhea,relieve the inflammatory reactions,improve the intestinal function and immune function,and stabilize the levels of serum SAA,TGF-β and 25(OH)D3.
