The value of total volume response and total mass response in the therapeutic evaluation of lung metastasis of hepatocarcinoma
10.3969/j.issn.1672-8467.2025.02.005
- VernacularTitle:总体积反应及总质量反应在肝癌肺转移疗效评估中的价值
- Author:
Jun-cheng WAN
1
;
Cai-hong YU
1
;
Chang-yu LI
1
;
Yong-jie ZHOU
1
;
Wei ZHANG
1
;
Jian-hua WANG
1
;
Zhi-ping YAN
1
;
Guo-wei YANG
1
;
Zhuo-yang FAN
1
;
Xu-dong QU
1
Author Information
1. 复旦大学附属中山医院介入治疗科 上海 200032;上海市影像医学研究所 上海 200032;国家放射与治疗临床医学研究中心 上海 200032
- Publication Type:Journal Article
- Keywords:
lung metastases;
hepatocarcinoma;
volume measurement;
mass measurement;
RECIST efficacy evaluation
- From:
Fudan University Journal of Medical Sciences
2025;52(2):201-208,231
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between lesion volume,lesion mass,and maximum lesion diameter in the assessment of advanced hepatocarcinoma with lung metastasis,and to evaluate the application value of total volume response and total mass response of lung metastatic lesions in efficacy assessment.Methods A retrospective analysis was conducted on the CT imaging data of 20 patients clinically confirmed with hepatocarcinoma and lung metastases,followed by subsequent follow-up to monitor their survival outcomes.Volume measurement software was used to measure the volume of lesions before and after treatment.We recored lesion diameter,volume measurements and CT values,calculated the mass of the lesions.The correlation between lesion volume,mass and diameter was analyzed,as well as the correlation between the change rates of volume,mass and lesion diameter.Additionally,the total volume and total mass of all lesions were calculated.The correlation between the change rates of total volume/total mass and the change rate of pulmonary lesion diameter under the RECIST 1.1 criteria,as well as the correlation with changes in patients'tumor markers,were analyzed.Furthermore,the overall volume response and overall mass response of lesions were evaluated based on changes in total volume and total mass,and their consistencies with the RECIST 1.1 criteria for efficacy evaluation were analyzed.Finally,univariate Cox regression analysis was performed to explore the association between these variables and patient survival outcomes.Results There was strong correlation between lesion volume,mass and tumor diameter(r=0.771,0.775),between the rate of change in mass and the rate of change in lesion diameter(r=0.846),and between the rates of change in total volume/total mass and the rate of change in pulmonary lesion diameter under the RECIST 1.1 criteria(r=0.800,0.896).The correlation between the rates of change in total volume/total mass and patients'tumor markers was not statistically significant.There was moderate correlation between the rate of change in volume and the rate of change in lesion diameter(r=0.692).The evaluation results of total volume response and total mass response for pulmonary lesions in advanced hepatocarcinoma with lung metastasis were generally consistent with the RECIST 1.1 criteria(Kappa=0.486,0.426).Univariate Cox regression analysis revealed that total lesion volume(P=0.047)and total lesion mass(P=0.049)were independent prognostic factors for survival outcomes.Conclusion Lesion volume,mass,and diameter,as well as their respective change rates,were found to be interrelated.Furthermore,total lesion volume and total lesion mass were identified as independent prognostic factors for survival outcomes.The total volume response and total mass response are promising evaluation methods in evaluating the efficacy of lung metastasis of hepatocarcinoma,which are different from the RECIST 1.1 evaluation criteria.
