Function of macrophages in pulmonary fibrosis
10.3969/j.issn.1000-484X.2025.03.001
- VernacularTitle:巨噬细胞在肺纤维化中的作用研究进展
- Author:
Zeting WANG
1
;
Yuyu JIANG
1
;
Xiaohui WANG
1
;
Yan XIANG
1
;
Xingguang LIU
1
Author Information
1. 海军军医大学免疫与炎症全国重点实验室,基础医学院病原生物学教研室,上海 200433
- Publication Type:Journal Article
- Keywords:
Macrophages;
Pulmonary fibrosis;
Metabolism;
Epigenetic regulation
- From:
Chinese Journal of Immunology
2025;41(3):513-521
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary fibrosis is a chronic progressive parenchymal lung lesion that is a common outcome of several interstitial lung diseases.Despite some progress in investigation of the etiology and pathogenesis of pulmonary fibrosis,it only achieves palliation and is difficult to cure.Lung macrophages are the most abundant innate immune cells in alveolar tissues,and there exists a great degree of heterogeneity and potential dynamic changes of lung macrophages at different stages of pulmonary fibrosis,whose dysfunction is closely related to the development of pulmonary fibrosis.Macrophages in the early stage of lung tissue injury mainly mediate the inflam-matory response.However,in the fibrotic stage,macrophages would be transformed into macrophages with a reparative phenotype that secrete large amounts of pro-fibrotic mediators and promote the proliferation and differentiation of fibroblasts,contributing to the pro-gression and deterioration of pulmonary fibrosis.The function of lung macrophages during fibrosis is regulated by a variety of mecha-nisms,including epigenetic modifications,metabolic reprogramming,and regulation of complex signaling pathways,etc.Strict func-tional regulation is critical for maintaining lung homeostasis and regulating injury repair.In this review,we will describe the heteroge-neity of macrophage and the underlying regulatory mechanisms during pulmonary fibrosis.
