Exploring the Potential Targets of Traditional Chinese Medicine for Lung Cancer Treatment Based on Intestinal Flora
10.16466/j.issn1005-5509.2025.05.014
- VernacularTitle:基于肠道关键菌探究中医药治疗肺癌的潜在靶点
- Author:
Xinyi LYU
1
;
Simin CHEN
1
;
Yanan WANG
1
Author Information
1. 北京中医药大学中医学院 北京 102488
- Publication Type:Journal Article
- Keywords:
lung cancer;
intestinal flora;
traditional Chinese medicine;
lung and intestinal axis;
simultaneous treatment of lung and intestine;
literature research;
clinical research;
NSCLC
- From:
Journal of Zhejiang Chinese Medical University
2025;49(5):617-621
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To explore the potential therapeutic targets of traditional Chinese medicine(TCM)in the treatment of lung cancer,based on the differences in gut microbiota,for providing new ideas for the TCM diagnosis and treatment of lung cancer.[Methods]Beginning with the TCM theories"Interior-exterior relationship between the lung and the large intestine"and"Simultaneous treatment of lung and intestine",integrating clinical research and empirical evidence,this study aims to clarify the feasibility of treating lung cancer by targeting gut microbiota and to summarize key gut microbiota targets in TCM for lung cancer treatment.[Results]Ancient Chinese medical literature and modern medical research provide a reliable theoretical basis for treating lung cancer based on intestinal microbiota.Empirical clinical prescriptions can regulate the composition and metabolism of gut microbiota.Some of the Chinese medicines in these prescriptions can specifically increase the abundance of key bacteria such as Lactobacillus,Faecalibacterium,and Bifidobacterium,thereby playing a positive role in the treatment of lung cancer.[Conclusion]There is a potential correlation between key gut microbiota in lung cancer patients and Chinese medicine,and regulating gut microbiota may be a target for TCM treatment of lung cancer.In depth exploration of the specific correlation between Chinese medicine and key bacteria,targeting the regulation of gut microbiota to formulate prescriptions,may become a new approach for TCM treatment of lung cancer.
