Efficacy and safety of esomeprazole combined with Biling Weitong granules in the treatment of epigastric pain syndrome
10.3969/j.issn.1673-9701.2025.10.012
- VernacularTitle:艾司奥美拉唑联合荜铃胃痛颗粒治疗上腹痛综合征的疗效与安全性研究
- Author:
Ying ZHANG
1
;
Yeliu WANG
;
Shuping ZHOU
Author Information
1. 蚌埠医科大学研究生院,安徽 蚌埠 233030
- Publication Type:Journal Article
- Keywords:
Epigastric pain syndrome;
Biling Weitong granules;
Esomeprazole;
Efficacy;
Safety
- From:
China Modern Doctor
2025;63(10):52-54,71
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of esomeprazole combined with Biling Weitong granules in the treatment of epigastric pain syndrome(EPS).Methods A total of 114 patients with EPS treated in the First Hospital of Anhui University of Science and Technology from January to June 2024 were selected and divided into control group and observation group according to random number table method,with 57 cases in each group.The control group was given oral esomeprazole magnesium enteric-coated tablets,and the observation group was given Biling Weitong granules on the basis of control group,the courses of treatment lasted for 8 weeks.The peripheral blood gastrin-17(G-17)level,the comprehensive score of middle and upper abdominal pain and/or burning sensation and the occurrence of adverse reactions were compared between two groups.Results After 4 and 8 weeks of treatment,the comprehensive scores of two groups were significantly lower than before treatment(P＜0.05),and the comprehensive scores of observation group were significantly lower than those of control group(P＜0.05).After 8 weeks of treatment,the effective rate of observation group was significantly higher than that of control group(x2=7.600,P=0.006).After 8 weeks of treatment,the G-17 levels in both groups were significantly lower than before treatment(P＜0.05),and the G-17 level in observation group was significantly lower than that in control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between two groups(x2=0.326,P=0.568).Conclusion Esomeprazole combined with Biling Weitong granules is more significant in improving the clinical symptoms of EPS patients,with higher treatment efficiency and good safety,which is worthy of clinical recommendation.
