Macrophage polarization mechanisms of diabetic foot ulcer and its targeted therapy
10.11816/cn.ni.2025-241323
- VernacularTitle:糖尿病足溃疡巨噬细胞极化机制及其靶向治疗
- Author:
Yulong MA
1
;
Yalong LI
;
Xiaoxia HU
;
Wenting LENG
;
Xinyue LIU
Author Information
1. 兰州大学第二医院检验医学实验中心,甘肃兰州 730000
- Publication Type:Journal Article
- Keywords:
Diabetic foot ulcer;
Macrophage polarization;
Chronic inflammation;
Wound healing
- From:
Chinese Journal of Nosocomiology
2025;35(9):1429-1434
- CountryChina
- Language:Chinese
-
Abstract:
As one of the most common and severe complications of diabetic mellitus,diabetic foot ulcers(DFUs)can result in severe tissue damage and dysfunction.Macrophage polarization is an important immune reactions,and the balance of macrophage polarization has remarkable impact on the occurrence,persistence and outcomes of inflammatory reactions.The imbalance of macrophage polarization may aggravate the inflammatory reactions of the diabetic mellitus patients,which therefore exacerbate the symptoms of the DFUs patients and bring more diffi-culties to the treatment.The adjustment of macrophage polarization may facilitate the improvement of symptoms and treatment.The influencing factors for the macrophage polarization and some of potential treatment measures for DFUs targeting the adjustment of macrophage polarization were reviewed in the article.
