Neuroprotective effect of non-invasive vagus nerve stimulation on rats with traumatic brain injury
10.16557/j.cnki.1000-7547.2025.01.008
- VernacularTitle:无创性迷走神经刺激对外伤性脑损伤模型大鼠的神经保护作用
- Author:
Yong LIANG
1
;
Zuolin SHI
1
;
Yu HUAN
1
;
Hai JIN
1
Author Information
1. 中国人民解放军北部战区总医院神经外科,沈阳 110016
- Publication Type:Journal Article
- Keywords:
non-invasive vagus nerve stimulation(nVNS);
traumatic brain injury(TBI);
controlled cortical im-pact(CCI);
cerebral edema;
neurotrophic factor;
rat
- From:
Chinese Journal of Neuroanatomy
2025;41(1):54-58
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the neuroprotective effect of non-invasive vagus nerve stimulation(nVNS)on traumatic brain injury(TBI).Methods:Male SD rats were used to prepare controlled cortical impact(CCI)rat mod-el.nVNS treatment was performed.The motor function of rats was detected by beam walking test.The water content of rats was evaluated by the dry-wet ratio of rat brain tissue.The content of lactate dehydrogenase(LDH)in cerebrospinal fluid was detected by commercial kit.The expression of bain-derived neurotrophic factor(BDNF)and nerve growth fac-tor(NGF)mRNA in rat cortex was detected by RT-qPCR.Results:After nVNS stimulation,CCI rats significantly im-proved the neurological function deficit,improved the motor ability,decreased the cerebral water content,decreased the level of LDH in cerebrospinal fluid,and upregulated the expression of BDNF and NGF mRNA in cortex.Conclusion:nVNS has a neuroprotective effect on TBI rats,and its mechanism may be related to the increased expression of BDNF and NGF.
