Research progress of osteoclasts in multidisciplinary treatment of tumor bone metastasis
10.12354/j.issn.1000-8179.2025.20250062
- VernacularTitle:破骨细胞在肿瘤骨转移多学科治疗中的研究进展
- Author:
Chen RUI
1
;
Cheng HONGJU
Author Information
1. 济宁医学院临床医学院(山东省 济宁市 272067)
- Publication Type:Journal Article
- Keywords:
osteoclast;
tumor bone metastasis;
treatment strategies;
nanotechnology;
immunotherapy
- From:
Chinese Journal of Clinical Oncology
2025;52(4):202-206
- CountryChina
- Language:Chinese
-
Abstract:
Up to 90%of cancer-related deaths worldwide are associated with tumor metastasis.In particular,bone metastases substantially reduces patient survival and quality of life.Abnormal osteoclast activation plays a crucial role in bone metastasis by promoting bone matrix degradation that exacerbates tumor growth and spread.Although osteoclast-targeting drugs,such as bisphosphonates,are widely used in clinical practice,adverse reactions limit their use.Further exploration of the mechanism of action of osteoclasts,as well as non-traditional drug treatments are required to prevent bone metastasis.This article reviews recent domestic and international research into multidisciplin-ary treatment strategies,including comprehensive chemotherapy,immunotherapy,and targeted therapy.The review aims to stimulate op-timization of clinical diagnosis and treatment strategies,development of novel treatment plans,and to provide a new theoretical basis and practical guidance for extending patient survival and improving quality of life.
