Mesenchymal stem cells:Immunodulatory effects and advances in immune thrombocytopenia
10.3969/j.issn.1000-484X.2025.03.040
- VernacularTitle:间充质干细胞的免疫调节作用及其在免疫性血小板减少症中的研究进展
- Author:
Chuanhui TANG
1
;
Ruiting WEN
1
;
Zhigang YANG
1
Author Information
1. 广东医科大学附属湛江中心医院血液内科,湛江 524037
- Publication Type:Journal Article
- Keywords:
Immune thrombocytopenia;
Mesenchymal stem cells;
Immune regulation;
Immunotherapy
- From:
Chinese Journal of Immunology
2025;41(3):740-742,750
- CountryChina
- Language:Chinese
-
Abstract:
Pathogenesis of immune thrombocytopenia(ITP)is complex,with a high reoccurence rate after first-line treatment and limited efficacy of second-line treatment,especially in refractory ITP,for which there is a lack of effective treatment.In recent years,it has been found that impaired function of mesenchymal stem cells(MSCs)is also involved in pathogenesis of ITP in addition to humoral and cellular immunity.Exogenous infusion of MSCs or endogenous restoration of immunomodulatory function of MSCs is expected to be an effective treatment strategy for ITP.Therefore,this article reviews biological characteristics and immunomodulatory effects of MSCs and their research progress in ITP,with aim of providing new ideas for further elucidating pathogenesis and exploring effective treatment options of ITP.
