Research progress of γδ T cells in head and neck squamous cell carcinoma

VernacularTitle:γδ T细胞在头颈部鳞状细胞癌中的研究进展
Author: Lu RUONAN ¹ ; Mao XINHUI ; Xue JIYAO ; Zheng YIJING ; Huang LIANG ; Dou YUTING ; Gui YUN ; Shi YI
Author Information

1. 上海市浦东新区浦南医院检验科(上海市 200125);温州医科大学附属第一医院第一临床医学院
Publication Type:Journal Article
Keywords: γδ T cells; head and neck squamous cell carcinoma(HNSCC); immune microenvironment
From: Chinese Journal of Clinical Oncology 2025;52(4):193-197
CountryChina
Language:Chinese
Abstract: Head and neck squamous cell carcinoma(HNSCC)is a highly prevalent malignancy with poor prognosis.Treatment strategies to date have achieved limited success in significantly improving overall survival rates.γδ T cells,a unique subset of immune cells in the tumor microenvironment,can link adaptive and innate immune functions.While γδ T cells can effectively recognize and eliminate HNSCC tumor cells,certain subsets of these cells can secrete interleukin-17,contributing to tumor progression.Nevertheless,due to their remarkable cyto-toxic activity,γδ T cells have been identified as promising candidates for antitumor immunotherapy.This article reviews the biological back-ground of γδ T cells,their role in tumor immunity in HNSCC,and recent advances in γδ T cell immunotherapy,aiming to provide new in-sights into HNSCC diagnosis and treatment.