Quality evaluation of Chuanxiong Chatiao Pills based on UPLC fingerprints,chemometrics and content determination
10.3969/j.issn.1001-1528.2025.06.001
- VernacularTitle:基于UPLC指纹图谱、化学计量学和含量测定的川芎茶调丸质量评价
- Author:
Zhuo XUE
1
;
Hui-yong LI
1
;
Huan CAO
1
;
Xue-yan BI
1
Author Information
1. 黑龙江省药品检验研究院,国家药品监督管理局中药质量研究与评价重点实验室,黑龙江省中药质量研究与评价重点实验室,黑龙江哈尔滨 150088
- Publication Type:Journal Article
- Keywords:
Chuanxiong Chatiao Pills;
quality evaluation;
UPLC fingerprints;
chemometrics;
content determination
- From:
Chinese Traditional Patent Medicine
2025;47(6):1773-1781
- CountryChina
- Language:Chinese
-
Abstract:
AIM To evaluate the quality of Chuanxiong Chatiao Pills.METHODS The UPLC fingerprints were established,after which hierarchical cluster analysis,principal component analysis,orthogonal partial least squares discriminant analysis were performed,the contents of cimifugin,ferulic acid,liquiritin,nodakenin,senkyunolide Ⅰ,5-O-methylvisamminol,rosmarinic acid,ammonium glycyrrhizinate,imperatorin and isoimperatorin were determined.RESULTS There were 18 common peaks in the fingerprints for 44 batches of samples with the similarities of 0.75-1.00.Various batches of samples were clustered into 2 catagories,3 principal components demonstrated the accumulative variance contribution rate of 87.1％,5 quality difference markers were screened.Ten constituents showed good linear relationships within their own ranges(r≥0.999 3),whose average recoveries were 90.22％-105.30％with the RSDs of 0.66％-1.98％,whose content ranges were 0.070-0.438,0.147-0.529,0.052-0.444,1.228-6.934,0.016-0.545,0.049-1.554,0.018-0.415,0.382-2.187,0.568-3.700,0.069-0.996 mg/g,respectively.CONCLUSION This accurate,reliable and specific method can provide scientific evidence for the quality control and standardization of Chuanxiong Chatiao Pills.
