Research progress of SLAMF6 in tumor immunity
10.3969/j.issn.1000-484X.2025.03.042
- VernacularTitle:SLAMF6在肿瘤免疫中的研究进展
- Author:
Shunhao ZHANG
1
;
Jing SUN
1
;
Qingyu DONG
1
;
Xudong WANG
1
Author Information
1. 南通大学附属医院医学检验科,南通 226001
- Publication Type:Journal Article
- Keywords:
SLAMF6;
CD8+T cell;
Autoimmunity;
Tumor immunity
- From:
Chinese Journal of Immunology
2025;41(3):751-755,759
- CountryChina
- Language:Chinese
-
Abstract:
Signaling lymphocyte activation molecule family 6(SLAMF6)is widely expressed in T,B lymphocytes,NK cells and other immune cells.As a self-binding receptor for homotypic interactions,SLAMF6 is a type Ⅰ transmembrane protein belonging to the immunoglobulin superfamily,composed of the proximal IgC2 domain and distal IgV domain,the extracellular membrane,and three unique tyrosine cytoplasmic signaling motifs.This article summarizes the structure,expression,function and implication for au-toimmunity and tumor immunity of SLAMF6.
