Changes in the intestinal microbiota structure of patients with colorectal adenoma
10.12354/j.issn.1000-8179.2025.20241679
- VernacularTitle:结直肠腺瘤患者肠道菌群结构发生改变
- Author:
Meng SIJIA
1
;
Li JIQIU
;
Wang DAN
;
Liu CHEN
;
Li CHUNYAN
;
Zhao JING
;
Wang YU
;
Du MEIZHI
;
Wang YUAN
;
Lu WENLI
;
Zhu YUN
;
Zhang KEMING
Author Information
1. 天津医科大学公共卫生学院流行病与卫生统计学系(天津市 300070)
- Publication Type:Journal Article
- Keywords:
colorectal adenoma(CRA);
intestinal microbiota;
16S rRNA;
next-generation sequencing;
cross-sectional study
- From:
Chinese Journal of Clinical Oncology
2025;52(4):177-182
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate gut microbiota differences between individuals with and without colorectal adenoma(CRA)and to identify gut microbes associated with CRA.Methods:This cross-sectional study analyzed the gut microbiota of 100 patients with CRA and 68 individuals without CRA(aged 40-75 years)who underwent colonoscopies between March 2021 and March 2022 at Tianjin Nankai Hospital.Fecal samples were sequenced for the V3-V4 region of the bacterial 16S rRNA gene using the Illumina NovaSeq platform.Results:Compared to the non-CRA group,the CRA group exhibited reduced relative abundances of identified and unidentified Lachnospiraceae,with increased Faecalibacterium and Streptococcus.In the non-CRA group,the relative abundances of Coprococcus,unidentified Clostridiaceae,and Clostridium were higher.LEfSe analysis revealed significant enrichment of Gammaproteobacteria,Proteobacteria,Enterobacteriales,and Faecalibacterium in the CRA group,while the non-CRA group was enriched for Moraxellaceae,Acinetobacter,and Anaerostipes.Conclusions:These findings suggest a discernible disparity in the gut microbiota structure between CRA patients and individuals without adenoma.The enrichment of potential pathogenic taxa,such as Faecalibacterium and Streptococcus,in the CRA group suggests a possible association with adenoma development.
