Study on the causal relationship between sarcopenia and cognitive impairment by using two-sample Mendelian randomization
10.3969/j.issn.1673-9701.2024.36.013
- VernacularTitle:应用双样本孟德尔随机化方法对肌肉减少症与认知障碍的因果关系的研究
- Author:
Yujie BI
1
;
Yuxin YANG
;
Leshi LIU
;
Dujun MA
;
Jing ZHAO
;
Qiuhui ZHONG
;
Houjun ZHU
Author Information
1. 广州中医药大学第四临床医学院,广东深圳 518033;深圳市中医院骨伤科,广东深圳 518033
- Publication Type:Journal Article
- Keywords:
Mendelian randomization;
Sarcopenia;
Cognitive impairment;
Cognitive performance;
Heritable variation
- From:
China Modern Doctor
2024;62(36):60-65
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the causal relationship between sarcopenia and cognitive impairment by using a two-sample Mendelian randomization(MR)study design.Methods Hand grip strength,usual walking pace,and appendicular lean mass(ALM)were identified as the primary exposure factors for sarcopenia,while cognitive function and cognitive performance associated with cognitive impairment were considered as the outcome.The MR statistical method was applied to examine the causal associations between both variables.Results The analysis revealed a positive correlation between sarcopenia,as indicated by hand grip strength,usual walking pace and ALM,and cognitive performance.Usual walking pace and ALM were positively associated with cognitive function.No significant causal relationship was detected between hand grip strength and cognitive function.In the reverse MR analysis,cognitive performance showed a positive correlation with usual walking pace and ALM,but no significant causal link was found with hand grip strength.Cognitive function was positively related to usual walking pace,but no significant associations were observed with hand grip strength and ALM.Conclusion Sarcopenia is associated with an increased risk of cognitive impairment,and a bidirectional causal relationship appears to exist between ALM and cognitive performance.
