Chemical constituents from the branches and leaves of Michelia yunnanensis and their anti-inflammatory activities
10.3969/j.issn.1001-1528.2025.06.017
- VernacularTitle:云南含笑枝叶化学成分及其抗炎活性研究
- Author:
Yi-fan SHEN
1
;
Ting-yue ZHENG
1
;
Qiu-hua WANG
1
;
Zhen-quan LI
1
;
Qiu-ye ZHAO
1
;
Liu-dong SONG
1
;
Lin-fen DING
1
Author Information
1. 昆明医科大学药学院暨云南省天然药物药理重点实验室,云南省现代生物医药产业学院,云南 昆明 650500
- Publication Type:Journal Article
- Keywords:
Michelia yunnanensis Franch.ex Finet & Gagnep.;
branches;
leaves;
chemical constituents;
isolation and identification;
anti-inflammatory activities
- From:
Chinese Traditional Patent Medicine
2025;47(6):1885-1891
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from the branches and leaves of Michelia yunnanensis Franch.ex Finet & Gagnep.and their anti-inflammatory activities.METHODS The methanol extract was isolated and purified by silica gel,MCI,Sephadex LH-20 and semi-preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.Their anti-inflammatory activities were evaluated by RAW264.7 model.RESULTS Twenty compounds were isolated and identified as dihydrodehydrodiconifenyl alcohol(1),8-hydroxypinoresinol(2),lariciresinol(3),isolariciresinol(4),(7S,8R)-4-hydroxy-3,3',5'-trimethoxy-8',9'-dinor-8,4'-oxyneoligna-7,9-diol-7'-aldehyde(5),thero-2,3-bis-(4-hydroxy-3-methoxypheyl)-3-methoxy-propanol(6),evofolin B(7),(E)-p-coumaryl alcohol γ-O-methyl ether(8),ω-hydroxypropioguaiacone(9),sinapaldehyde(10),isoscopoletin(11),6-hydroxy-5,7-dimethoxycoumarin(12),2α,3α-dihydroxy-2-methylbutyrolactone(13),6-hydroxy-3(1-hydroxy-1-methylethyl)-6-methyl-2-cyclohexen-1-one(14),benzofuran-2-carboxaldehyde(15),3,4-dihydroxy-5-methoxybenzaldehyde(16),3,5-dimethoxy-4-hydroxybenzaldehyde(17),3,4-dihydroxybenzaldehyde(18),3,4-dihydroxybenzoic methyl ester(19),vanillic acid(20).The inhibition rate of compound 1 on NO was 45.39％±0.32％.CONCLUSION Compounds 1-16,18-20 are first isolated from this plant.Compound 1 has anti-inflammatory activity.
