Clinical effects of Salvia miltiorrhiza combined with indobufen on restenosis in patients with autologous arteriovenous fistula after PTA
10.3969/j.issn.1001-1528.2025.06.013
- VernacularTitle:丹参联合吲哚布芬对自体动静脉内瘘患者PTA术后再狭窄的临床疗效
- Author:
Tian-yi WANG
1
;
Jun WU
1
;
Hong ZHANG
1
Author Information
1. 安庆市第一人民医院肾内科,安徽安庆 246003
- Publication Type:Journal Article
- Keywords:
Salvia miltiorrhiza Bunge;
indobufen;
autologous arteriovenous fistula;
percutaneous transluminal angioplasty(PTA);
restenosis
- From:
Chinese Traditional Patent Medicine
2025;47(6):1866-1870
- CountryChina
- Language:Chinese
-
Abstract:
AIM To explore the clinical effects of Salvia miltiorrhiza Bunge combined with indobufen on restenosis in patients with autologous arteriovenous fistula after percutaneous transluminal angioplasty(PTA).METHODS Sixty-five patients were randomly assigned into control group(32 cases)for administration of indobufen,and observation group(33 cases)for administration of both Danshen Tablets and indobufen.The changes in internal fistula diameter,internal fistula blood flow,platelet aggregation rate,coagulation function indices(APTT,PT,TT,FIB),inflammatory factors(IL-6,IL-1β,TNF-α),restenosis rate and incidence of adverse reactions were detected.RESULTS At 3,6 months after surgery,the observation group demonstrated bigger internal fistula diameter and internal fistula blood flow than the control group(P＜0.05).At 6 months after surgery,the two groups displayed decreased platelet aggregation rate,FIB,inflammatory factors(P＜0.05),and prolonged APTT,PT,TT(P＜0.05),especially for the observation group(P＜0.05).No significant differences in restenosis rate and incidence of adverse reactions were found between the two groups(P＞0.05).CONCLUSION For the patients with autologous arteriovenous fistula after PTA,S.miltiorrhiza combined with indobufen can safely and effectively inhibit the reduced progresses of internal fistula diameter and internal fistula blood flow,maintenance the patency of internal fistula,and alleviate platelet aggregation and body inflammatory responses.
