Evaluation function of human neutrophil peptides with for severity and prognosis of patients with acute respiratory distress syndrome
10.3969/j.issn.1673-9701.2024.36.008
- VernacularTitle:人中性粒细胞多肽对急性呼吸窘迫综合征患者病情及预后的评估作用
- Author:
Sulong WU
1
;
Wenmei ZENG
;
Yue ZHENG
;
Yimin LI
Author Information
1. 深圳市前海蛇口自贸区医院急诊重症医学科,广东深圳 518067
- Publication Type:Journal Article
- Keywords:
Acute respiratory distress syndrome;
Human neutrophil peptides;
Acute physiology and chronic health evaluation-Ⅱ score;
Prognosis
- From:
China Modern Doctor
2024;62(36):37-40,118
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate function of human neutrophil peptides(HNPs)for the severity and prognosis of patients with acute respiratory distress syndrome(ARDS).Methods From December 2021 to December 2023,80 ARDS patients were enrolled in the study from the intensive care unit(ICU)of Shenzhen Qianhai Shekou Free Trade Zone Hospital.Plasma samples were taken within 24 hours after admission to ICU,HNPs concentration was then measured with enzyme-linked immunesorbent assay.Differences in HNPs concentration and acute physiology and chronic health evaluation-Ⅱ(APACHE Ⅱ)score etc.Clinical index parameters were compared in survival group(n=48)and death group(n=32)based on their 28-day outcomes.The correlation between HNPs concentration and APACHE Ⅱ score were calculated by Spearman correlation analysis.We analyzed the risk factors for 28 days death of ARDS patients by single-factor Logistic regression,then used the significant risk factors to analyze death odds ratio by multivariate Logistic regression analysis.Results HNPs concentration and APACHE Ⅱ score of death group was significantly increased than those of survival group(P<0.001).HNPs concentration has a positive correlation with APACHE Ⅱ score(r=0.344,P<0.001).HNPs and APACHE Ⅱ were independent prognosis factor of 28-day mortality of ARDS patients.Conclusion Plasma HNPs concentration may be early used to evaluate the severity and prognosis of ARDS patients.
