The therapeutic efficacy and neuroplasticity effects of moderate-intensity aerobic exercise in patients with chronic schizophrenia
10.3969/j.issn.1673-9701.2024.36.002
- VernacularTitle:中等强度有氧运动对慢性精神分裂症患者的疗效及神经可塑性作用的研究
- Author:
Yu HUANG
1
;
Cheng ZHU
;
Jiahong LIU
;
Zhen HUANG
;
Anle PAN
Author Information
1. 温州医科大学附属康宁医院普通精神科 浙江省精神心理疾病临床医学研究中心,浙江温州 325000
- Publication Type:Journal Article
- Keywords:
Aerobic exercise;
Chronic schizophrenia;
Neuroplasticity;
Cognitive function;
Social function
- From:
China Modern Doctor
2024;62(36):7-11
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effectiveness of moderate-intensity aerobic exercise in patients with chronic schizophrenia,focusing on its effects on neuroplasticity markers such as serum brain-derived growth factor(BDNF)and insulin-like growth factor-1(IGF-1),and analyze the relationship between therapeutic efficacy and neuroplasticity indicators.Methods A total of 200 schizophrenic patients treated at the Affiliated Kangning Hospital of Wenzhou Medical University from January 2021 to December 2023 were selected and randomly divided into study group and control group,100 patients in each group based on a random number table.The positive and negative syndrome scale(PANSS)was used to assess the patients'psychiatric symptoms before and after treatment.The repeatable battery for the assessment of neuropsychological status(RBANS)was employed to evaluate the patients'cognitive function,while the social functioning in psychosis patient inventory(SSFPI)was used to assess their social function.Additionally,the levels of BDNF and IGF-1 in the patients'peripheral blood were measured.Differences in relevant indicators before and after treatment were compared,and influencing factors were analyzed.Results ①Compared with control group,patients in study group exhibited significant improvements in cognitive function(RBANS total score,immediate memory score,visual span score),social function(SSFPI total score,daily living ability score,kineses and social interaction score,social activity skill score),and neuroplasticity indicators(BDNF and IGF-1 differences)(P<0.05);②After treatment,the IGF-1 difference in patients'serum was positively correlated with the improvement in visual span within cognitive function.Furthermore,the differences in BDNF and IGF-1 were also positively correlated with improvements in multiple indicators of social function,including SSFPI total score,daily living ability,kineses and social interaction,and social activity skills(P<0.05);③Stepwise regression analysis revealed that the differences in BDNF and IGF-1 could predict the degree of improvement in SSFPI total score and various factor scores,accounting for 37.90%to 41.70%of the variation.Conclusion Moderate intensity aerobic exercise can improve cognitive function in patients with chronic schizophrenia,mainly including immediate memory,visual breadth,and social function.The specific mechanism may be related to the elevated levels of BDNF and IGF-1 in patients.
